Absence of amnestic effect of an anxiolytic 5-HT3 antagonist (BRL 46470A) injected into basolateral amygdala, as opposed to diazepam
MA de Souza Silva, FS Guimarães, FG Graeff… - Behavioural brain …, 1993 - Elsevier
This experiment compares the effects of microinjections into the basolateral amygdala
nucleus of diazepam (DZP) and a new 5-HT 3 receptor antagonist, BRL 46470A, on
aquisition and retention of an inhibitory avoidance task by rats. The animals were
microinjected with DZP or BRL 46470A between 10 and 15 min before the learning trial.
Retention testing 48 h later showed impaired retention in animals injected with DZP but not
with BRL 46470A. These results show that BRL 46470A, a compound suggested to have …
nucleus of diazepam (DZP) and a new 5-HT 3 receptor antagonist, BRL 46470A, on
aquisition and retention of an inhibitory avoidance task by rats. The animals were
microinjected with DZP or BRL 46470A between 10 and 15 min before the learning trial.
Retention testing 48 h later showed impaired retention in animals injected with DZP but not
with BRL 46470A. These results show that BRL 46470A, a compound suggested to have …
